abstract：:The aims of this study are to determine the replacement rate of damaged hepatocytes by donor-derived cells in sex-mismatched recipient patients with thalassemia major and to determine whether co-transplantation of mesenchymal stem cells and hematopoietic stem cells (HSCs) can alleviate liver fibrosis. Ten sex-mismatch...

journal_title：Annals of hematology

authors： Ghavamzadeh A,Sotoudeh M,Hashemi Taheri AP,Alimoghaddam K,Pashaiefar H,Jalili M,Shahi F,Jahani M,Yaghmaie M

更新日期：2018-02-01 00:00:00

abstract：:Interstitial pneumonia (IP) is a lethal complication in lymphoma patients undergoing chemotherapy. A total of 2212 consecutive patients diagnosed with lymphoma between 2009 and 2014 were enrolled in the present study. IP was defined as diffuse pulmonary interstitial infiltrate found on computed tomography scans. IP wa...

journal_title：Annals of hematology

authors： Liu WP,Wang XP,Zheng W,Xie Y,Tu MF,Lin NJ,Ping LY,Ying ZT,Zhang C,Deng LJ,Ding N,Wang XG,Song YQ,Zhu J

更新日期：2018-01-01 00:00:00

abstract：:Follicular lymphoma (FL) is a low-grade lymphoma that is usually characterized by generalized lymphadenopathy. Extranodal invasion by FL generally involves the bone marrow, skin, and duodenum; splenic infiltration often occurs in the advanced stages. However, primary splenic FL is very rare. Hence, few studies have be...

journal_title：Annals of hematology

authors： Shimono J,Miyoshi H,Kamimura T,Eto T,Miyagishima T,Sasaki Y,Kurita D,Kawamoto K,Nagafuji K,Seto M,Teshima T,Ohshima K

更新日期：2017-12-01 00:00:00

abstract：:The hypomethylating agents azacytidine and decitabine are unaffordable for many patients with MDS. The combination of the DNA methyltransferase inhibitor hydralazine and the histone deacetylase inhibitor valproate has shown preliminary efficacy in MDS. The aim of this study is to evaluate the clinical efficacy and saf...

journal_title：Annals of hematology

authors： Candelaria M,Burgos S,Ponce M,Espinoza R,Dueñas-Gonzalez A

更新日期：2017-11-01 00:00:00

abstract：:The clinical impact of KIT mutations in core binding factor acute myeloid leukemia (CBF-AML) is still unclear. In the present study, we analyzed the prognostic significance of each KIT mutation (D816, N822K, and other mutations) in Japanese patients with CBF-AML. We retrospectively analyzed 136 cases of CBF-AML that h...

journal_title：Annals of hematology

authors： Yui S,Kurosawa S,Yamaguchi H,Kanamori H,Ueki T,Uoshima N,Mizuno I,Shono K,Usuki K,Chiba S,Nakamura Y,Yanada M,Kanda J,Tajika K,Gomi S,Fukunaga K,Wakita S,Ryotokuji T,Fukuda T,Inokuchi K

更新日期：2017-10-01 00:00:00

abstract：:Telomere shortening represents an established mechanism connecting aging and cancer development. We sequentially analyzed telomere length (TL) of 49 acute myeloid leukemia (AML) patients at diagnosis (n = 24), once they achieved complete cytological remission (CCR) and/or during refractory disease or relapse and after...

journal_title：Annals of hematology

authors： Ventura Ferreira MS,Crysandt M,Ziegler P,Hummel S,Wilop S,Kirschner M,Schemionek M,Jost E,Wagner W,Brümmendorf TH,Beier F

更新日期：2017-09-01 00:00:00

abstract：:We integrated molecular data with available prognostic factors in patients undergoing allogeneic hematopoietic cell transplantation (alloHCT) for myelodysplastic syndrome (MDS) or secondary acute myeloid leukemia (sAML) from MDS to evaluate their impact on prognosis. Three hundred four patients were sequenced for muta...

journal_title：Annals of hematology

authors： Heuser M,Gabdoulline R,Löffeld P,Dobbernack V,Kreimeyer H,Pankratz M,Flintrop M,Liebich A,Klesse S,Panagiota V,Stadler M,Wichmann M,Shahswar R,Platzbecker U,Thiede C,Schroeder T,Kobbe G,Geffers R,Schlegelberger B,Gö

更新日期：2017-08-01 00:00:00

abstract：:Hemophagocytic lymphohistiocytosis (HLH) is a rare multisystem disorder characterized by proliferation and diffuse infiltration multiple organs with histiocytes, including the central nervous system (CNS). Neurological manifestations of HLH have been recognized in different studies with children, but they remain relat...

journal_title：Annals of hematology

authors： Cai G,Wang Y,Liu X,Han Y,Wang Z

更新日期：2017-08-01 00:00:00

abstract：:The most common causes of morbidity and mortality in myeloproliferative neoplasms (MPN) are thrombotic and hemorrhagic complications. The JAK2V617F mutation, commonly found in MPN, correlates with several clinical and laboratory characteristics even if the relevance of JAK2V617F allele burden in the natural history of...

journal_title：Annals of hematology

authors： Bertozzi I,Bogoni G,Biagetti G,Duner E,Lombardi AM,Fabris F,Randi ML

更新日期：2017-08-01 00:00:00

abstract：:Obesity is a well-known risk factor for the development of cancer, but its influence on the course of disease is still controversial. We investigated the influence of body mass index (BMI) on overall survival (OS) in 502 patients with indolent non-Hodgkin's lymphoma or mantle cell lymphoma in a subgroup analysis of th...

journal_title：Annals of hematology

authors： Weiss L,Melchardt T,Egle A,Hopfinger G,Hackl H,Greil R,Barth J,Rummel M

更新日期：2017-07-01 00:00:00

abstract：:An improvement in quality of life and survival occurred among thalassemia major (TM) patients: pregnancy in such patients has become a reality. Safe pregnancy and delivery require efforts to ensure the best outcomes. Between 2007 and 2016, 30 TM patients had 37 pregnancies. We analyzed the hematological parameters bef...

journal_title：Annals of hematology

authors： Cassinerio E,Baldini IM,Alameddine RS,Marcon A,Borroni R,Ossola W,Taher A,Cappellini MD

更新日期：2017-06-01 00:00:00

abstract：:Interferon-α (IFNα) was the first effective drug therapy for hairy cell leukemia (HCL). Nowadays, it is used as an alternative treatment in selected patients. Due to unlimited treatment time, monitoring and early prediction of response are important. Moreover, IFNα is used in the therapy of chronic hepatitis C, where ...

journal_title：Annals of hematology

authors： Jud S,Goede JS,Senn O,Spanaus K,Manz MG,Benz R

更新日期：2017-05-01 00:00:00

abstract：:Allogeneic hematopoietic stem cell transplantation (allo-SCT) is a therapeutic option for relapsed, advanced, and otherwise incurable non-Hodgkin's lymphomas (NHL) suggested by the existence of a graft-versus-lymphoma effect. The main complications are graft-versus-host disease and infections. We performed a retrospec...

journal_title：Annals of hematology

authors： Picleanu AM,Novelli S,Monter A,Garcia-Cadenas I,Caballero AC,Martino R,Esquirol A,Briones J,Sierra J

更新日期：2017-05-01 00:00:00

abstract：:Eculizumab is indicated for the therapy of patients with symptomatic paroxysmal nocturnal hemoglobinuria (PNH). Due to inhibition of terminal complement cascade, patients on eculizumab are susceptible to Neisseria meningitidis infections. The two mainstays to reduce the risk of infection are vaccination and antibiotic...

journal_title：Annals of hematology

authors： Alashkar F,Vance C,Herich-Terhürne D,Preising N,Dührsen U,Röth A

更新日期：2017-04-01 00:00:00

abstract：:Although the outcome of patients with acute myeloid leukemia (AML) has improved by optimized chemotherapy regimens and bone marrow transplantation, leukemia relapse remains one of the most challenging problems during therapy. Sustained existence of AML blasts is a fundamental determinant for the development of leukemi...

journal_title：Annals of hematology

authors： Liu J,Qin YZ,Yang S,Wang Y,Chang YJ,Zhao T,Jiang Q,Huang XJ

更新日期：2017-04-01 00:00:00

abstract：:Elderly and infirm patients with acute myeloid leukemia (AML) with either induction refractory or relapse disease may benefit from treatment with azacitidine. We retrospectively reviewed the data from five tertiary centers in Israel, treated between 2009 and 2015. Thirty-four patients (median age 74 years) were identi...

journal_title：Annals of hematology

authors： Ram R,Gatt M,Merkel D,Helman I,Inbar T,Nagler A,Avivi I,Ofran Y

更新日期：2017-04-01 00:00:00

abstract：:Cancer incidence in patients with recurrent unprovoked venous thromboembolism (VTE) is much higher than after a first event, but the incidence of myeloproliferative neoplasms (MPN) in this situation is still unknown. We tested for JAK2V617F and calreticulin mutants, 372 DNA samples of patients treated for (VTR). Among...

journal_title：Annals of hematology

authors： Ianotto JC,Chauveau A,Mottier D,Ugo V,Berthou C,Lippert E,Delluc A

更新日期：2017-03-01 00:00:00

abstract：:Ruxolitinib, a JAK1 and JAK2 inhibitor, has been tested and approved for the treatment of primary and secondary myelofibrosis (MF). Aim of our study is to report safety and efficacy of ruxolitinib in 98 patients affected by MF treated outside clinical trials and collected and treated consecutively by the Lazio Coopera...

journal_title：Annals of hematology

authors： Breccia M,Andriani A,Montanaro M,Abruzzese E,Buccisano F,Cedrone M,Centra A,Villivà N,Celesti F,Trawinska MM,Massaro F,Di Veroli A,Anaclerico B,Colafigli G,Molica M,Spadea A,Petriccione L,Cimino G,Latagliata R

更新日期：2017-03-01 00:00:00

abstract：:Despite recent advances made in its treatment, multiple myeloma (MM) remains an incurable B cell malignancy. Thus, the objective for treating these patients is to prolong overall survival (OS) and preserve patients' quality of life. We have analyzed data from 264 consecutive MM patients who had their initial visit bet...

journal_title：Annals of hematology

authors： Berenson A,Vardanyan S,David M,Wang J,Harutyunyan NM,Gottlieb J,Halleluyan R,Spektor TM,Udd KA,Eshaghian S,Nassir Y,Eades B,Swift R,Berenson JR

更新日期：2017-03-01 00:00:00

abstract：:To investigate whether cytokine genetic polymorphisms influence the outcome of diffuse large B cell lymphoma (DLBCL), we tested 337 consecutive DLBCL treated with CHOP or rituximab-CHOP (R-CHOP) from interleukin 10 (IL10), Bcl-2, and tumor necrosis factor (TNF)-α polymorphisms. Patients who carried the IL10 rs1800871 ...

journal_title：Annals of hematology

authors： Liu D,Wang Y,Dong M,Guan S,Wang Y,Sun H,Wu N,Li S,Bai J,Chen F,Sun D,Jin Y

更新日期：2017-02-01 00:00:00

abstract：:Acquired aplastic anemia (AA) and paroxysmal nocturnal hemoglobinuria (PNH) are interrelated ultra-rare diseases. Quality of life (QoL) evaluation tools used in studies for AA and PNH are unspecific and designed for cancer patients (e.g., the European Organization for Research and Treatment of Cancer Quality of Life Q...

journal_title：Annals of hematology

authors： Groth M,Singer S,Niedeggen C,Petermann-Meyer A,Röth A,Schrezenmeier H,Höchsmann B,Brümmendorf TH,Panse J

更新日期：2017-02-01 00:00:00

abstract：:Because of the widespread use of immunosuppressive drugs, CMV infection is one of the most important causes of morbidity and mortality in patients with haematological malignancies worldwide. The aim of the study was to retrospectively analyse the epidemiology of CMV infection in haematological patients. Between 2008 a...

journal_title：Annals of hematology

authors： Piukovics K,Terhes G,Gurbity-Pálfi T,Bereczki Á,Rárosi F,Deák J,Borbényi Z,Urbán E

更新日期：2017-01-01 00:00:00

abstract：:Extreme thrombocytosis (ExT) has been associated with an increased bleeding risk in myeloproliferative neoplasm (MPN) patients and is included in the high risk category in treatment guidelines. Treatment of patients with ExT has not been studied in prospective trials. To study physicians' approaches to ExT, we distrib...

journal_title：Annals of hematology

authors： Koren-Michowitz M,Lavi N,Ellis MH,Vannucchi AM,Mesa R,Harrison CN

更新日期：2017-01-01 00:00:00

abstract：:Isocitrate dehydrogenase IDH 1 and IDH 2 mutations were reported in several cancer forms, especially in hematological malignancies, but were never been investigated in familial aggregation. The aim of this study is to determine whether germline isocitrate dehydrogenase genes mutations are involved.We targeted IDH1 and...

journal_title：Annals of hematology

authors： Hamadou WS,Bourdon V,Létard S,Brenet F,Laarif S,Besbes S,Paci A,David M,Penard-Lacronique V,Youssef YB,Laatiri MA,Eisinger F,Mari V,Gesta P,Dreyfus H,Bonadona V,Dugast C,Zattara H,Faivre L,Noguchi T,Khélif A,Sal

更新日期：2016-12-01 00:00:00

abstract：:Multiresistant bacterial infections are a potentially life-threatening condition in acute leukaemia (AL) patients. We aimed to better define the very recent epidemiology and outcome of bloodstream infections (BSIs) in a real-life setting. We prospectively collected all consecutive febrile/infectious episodes occurring...

journal_title：Annals of hematology

authors： Cattaneo C,Zappasodi P,Mancini V,Annaloro C,Pavesi F,Skert C,Ferrario A,Todisco E,Saccà V,Verga L,Passi A,Da Vià M,Ferrari S,Mometto G,Petullà M,Nosari A,Rossi G

更新日期：2016-12-01 00:00:00

abstract：:Extranodal natural killer (NK)/T cell lymphoma-associated hemophagocytic syndrome (HPS) (NK/T-LAHS) is a heterogeneous and life-threatening disease, which warrants investigation of its risk factors and clinical features. We retrospectively analyzed the clinical records of 202 patients with extranodal NK/T cell lymphom...

journal_title：Annals of hematology

authors： Jia J,Song Y,Lin N,Liu W,Ping L,Zheng W,Wang X,Xie Y,Tu M,Zhang C,Ying Z,Deng L,Ding N,Zhu J

更新日期：2016-12-01 00:00:00

abstract：:Currently, the diagnosis of acute graft-versus-host disease (aGVHD) is mainly based on clinical symptoms and biopsy results. This study was designed to further explore new no noninvasive biomarkers for aGVHD prediction/diagnosis. We profiled miRNAs in serum pools from patients with aGVHD (grades II-IV) (n = 9) and non...

journal_title：Annals of hematology

authors： Zhang C,Bai N,Huang W,Zhang P,Luo Y,Men S,Wen T,Tong H,Wang S,Tian YP

更新日期：2016-10-01 00:00:00

abstract：:Neutrophil-lymphocyte ratio (NLR), an indicator of inflammation, has been lately demonstrated as a prognostic factor and an indicator of disease activity in various diseases. However, the effects of NLR have not been investigated in mycosis fungoides (MF) patients yet. The aim of this study is to investigate the relat...

journal_title：Annals of hematology

authors： Eren R,Nizam N,Doğu MH,Mercan S,Erdemir AV,Suyanı E

更新日期：2016-10-01 00:00:00

abstract：:Allogeneic hematopoietic cell transplantation (allo-HCT) remains the only curative treatment option for myelofibrosis (MF) despite the emergence of novel targeted therapies. To reduce graft rejection and graft-versus-host disease (GvHD), current allo-HCT protocols often include in vivo T lymphocyte depletion using pol...

journal_title：Annals of hematology

authors： Ecsedi M,Schmohl J,Zeiser R,Drexler B,Halter J,Medinger M,Duyster J,Kanz L,Passweg J,Finke J,Bethge W,Lengerke C

更新日期：2016-10-01 00:00:00

abstract：:Early mortality remains a major challenge for the treatment of hemophagocytic lymphohistiocytosis (HLH), which warrants the need for prompt risk stratification in the early phase of the disease. We retrospectively analyzed clinical features of a cohort of pediatric patients managed at a tertiary hospital in southern C...

journal_title：Annals of hematology

authors： Bin Q,Gao JH,Luo JM

更新日期：2016-09-01 00:00:00

abstract：:The cytogenetic and molecular data is recognized as the most valuable prognostic factor in acute myeloid leukemia (AML). Our aim was to systemically analyze the cytogenetics of Korean AML patients and to compare the cytogenetic profiles of various races to identify possible geographic heterogeneity. We retrospectively...

journal_title：Annals of hematology

authors： Byun JM,Kim YJ,Yoon HJ,Kim SY,Kim HJ,Yoon J,Min YH,Cheong JW,Park J,Lee JH,Hong DS,Park SK,Kim HJ,Ahn JS,Shin HJ,Chung JS,Lee WS,Lee SM,Park Y,Kim BS,Lee JH,Lee KH,Jung CW,Jang JH,Min WS,Park TS,AML\/M

更新日期：2016-08-01 00:00:00

abstract：:We retrospectively evaluated the role of rituximab (R) in maintenance treatment after autologous stem cell transplantation performed in patients with relapsed follicular lymphoma. We compared the outcome of 67 follicular lymphoma (FL) patients according to the use of rituximab maintenance (RM) or not. All patients rec...

journal_title：Annals of hematology

authors： Bourcier J,Gastinne T,Leux C,Moreau A,Bossard C,Mahé B,Blin N,Dubruille V,Touzeau C,Voldoire M,Guillaume T,Peterlin P,Gallas P,Garnier A,Maisonneuve H,Moreau P,Juge-Morineau N,Jardel H,Chevallier P,Moreau P,Le Gou

更新日期：2016-08-01 00:00:00

abstract：:The effects of romiplostim on bone marrow morphology were evaluated in adults with immune thrombocytopenia (ITP). Patients with platelet counts <50 × 10(9)/L, ≥1 prior ITP therapies, and no collagen at baseline received weekly subcutaneous romiplostim starting at 1 μg/kg, adjusted to maintain platelet counts between 5...

journal_title：Annals of hematology

authors： Janssens A,Rodeghiero F,Anderson D,Chong BH,Boda Z,Pabinger I,Červinek L,Terrell DR,Wang X,Franklin J

更新日期：2016-06-01 00:00:00

abstract：:Patients with chronic lymphocytic leukemia (CLL) who receive chemoimmunotherapy and do not achieve complete remission experience significantly shortened progression-free interval (PFS). Additionally, the majority of patients treated for relapsed disease demonstrate evidence of measurable disease. Eradication of minima...

journal_title：Annals of hematology

authors： Awan FT,Jones JA,Maddocks K,Poi M,Grever MR,Johnson A,Byrd JC,Andritsos LA

更新日期：2016-06-01 00:00:00

abstract：:Treatment of relapse and primary progression in aggressive lymphoma remains unsatisfactory; outcome is still poor. Better treatment strategies are much needed for this patient population. The R1 study is a prospective multi-center phase I/II study evaluating a dose finding approach with a triple transplant regimen in ...

journal_title：Annals of hematology

authors： Hohloch K,Zeynalova S,Chapuy B,Pfreundschuh M,Loeffler M,Ziepert M,Feller AC,Trümper L,Hasenclever D,Wulf G,Schmitz N

更新日期：2016-06-01 00:00:00

abstract：:Gastric MALT lymphoma is closely associated with Helicobacter pylori infection. Bacterial eradication therapy comprising clarithromycin is the first-line treatment in gastric MALT lymphoma patients. However, antimicrobial resistance to clarithromycin has been increasing in Europe, and thus far, it has not been examine...

journal_title：Annals of hematology

authors： Bilgilier C,Simonitsch-Klupp I,Kiesewetter B,Raderer M,Dolak W,Makristathis A,Steininger C

更新日期：2016-06-01 00:00:00

abstract：:Primary myelofibrosis (PMF)-associated pruritus is often severe and requires treatment. Fifty-one patients with bone marrow-proven PMF with associated pruritus were identified from a primary cohort of patients with PMF (n = 566) seen at our institution. We conducted a retrospective review of the clinical characteristi...

journal_title：Annals of hematology

authors： Vaa BE,Tefferi A,Gangat N,Pardanani A,Lasho TL,Finke CM,Wolanskyj AP

更新日期：2016-06-01 00:00:00

abstract：:To explore the clinicopathological characteristics and outcomes of light chain deposition disease (LCDD) in a Chinese population, we retrospectively studied the clinicopathological data, treatment, and outcomes of 48 patients with biopsy-proven LCDD from a single center. Among the patients, there were 29 males and 19 ...

journal_title：Annals of hematology

authors： Li XM,Rui HC,Liang DD,Xu F,Liang SS,Zhu XD,Huang XH,Liu ZH,Zeng CH

更新日期：2016-05-01 00:00:00

abstract：:It is often difficult for standard blood banks in Korea to supply adequate amounts of blood for patients with rare phenotype. Moreover, the definition of a blood in need is ambiguous, and much remains to be learned. In this study, we determined the prevalence of various red blood cell (RBC) antigens from a donor viewp...

journal_title：Annals of hematology

authors： Hong YJ,Chung Y,Hwang SM,Park JS,Kwon JR,Choi YS,Kim JN,Lee DH,Kwon SY,Cho NS,Song EY,Park KU,Song J,Han KS

更新日期：2016-05-01 00:00:00

abstract：:Bortezomib is one of the most widely used novel drugs for the treatment of multiple myeloma (MM). However, twice-weekly intravenous administration is associated with innegligible adverse events and treatment discontinuation. We therefore evaluated the long-term efficacy and feasibility of reduced frequency treatment w...

journal_title：Annals of hematology

authors： Ozaki S,Hata H,Abe M,Saitoh T,Hanamura I,Yano H,Sunami K,Kosugi H,Sawamura M,Nakazato T,Masunari T,Mori M,Takagi T,Murakami H,Shimizu K

更新日期：2016-05-01 00:00:00